Pseudomonas aeruginosa skin and soft tissue infections uptodate pdf

Pseudomonas aeruginosa skin and soft tissue infections uptodate pdf
The opportunistic gram-negative bacterium Pseudomonas aeruginosa is implicated in many chronic infections and is readily isolated from chronic wounds, medical devices, and the lungs of cystic
Abstract. Skin and soft-tissue infections due to Pseudomonas aeruginosa were treated with intravenous infusions or intramuscular injections of cefsulodin sodium in an open, multi-center study.
table i (continued) a list of the major findings and compijcations of pseudomonas septicemia in twenty-three patients l a 2 patient, age (yr.) and
Skin and Soft Tissue Infections Cellulitis Note: The most common etiology of cellulitis with purulent drainage is S. aureus, although Group A streptococci and …
Multiple antibiotic resistant Pseudomonas aeruginosa is a significant cause of burn wound infections and, skin and soft tissue infections. Because of its resistance to commonly used antibiotics and antiseptics, there is a shortage of therapeutic options for effective treatment.
Gram-negative bacilli Pseudomonas aeruginosa is an important pathogen in hospitalized patients, contributing to their morbidity and mortality due to its multiple resistance mechanisms. Therefore, as therapeutic options become restricted,
Anti-tumor necrosis factor alpha (TNF-α) therapy has been associated with an increased risk of granulomatous infections. We present a case of osteomyelitis and soft tissue abscess caused by Pseudomonas aeruginosa following the use of etanercept, a recombinant protein composed of the TNF-α receptor fused to human immunoglobulin (IgG).
1Internal Medicine Department-Infectious Disease Unit, Complejo Hospitalario Universitario de Vigo, Vigo, Spain *
Skin and soft tissue infections (SSTIs) due to Pseudomonas oryzihabitans are very rare. The aim of the present study was to investigate the clinical and microbiological characteristics of this
Pseudomonas aeruginosa is a major cause of nosocomial infections. This organism shows a remarkable This organism shows a remarkable capacity to resist antibiotics, either intrinsically (because of constitutive expression of b-lactamases and
This information may then be used to determine whether antipseudomonal antibiotic drug therapy is indicated for DFI at this facility. were processed per routine laboratory protocol. or drainage at the suspected site of bone infection) plus an organism cultured from blood.388C. tenderness.bial skin and soft-tissue infections that include P aeruginosa can occur in the absence of antibiotic
Necrotizing fasciitis (NF) is a severe soft tissue potentially fatal bacterial infection characterized by rapid progressing necrosis involving mainly the fascia and subcutaneous tissue but can also extend to involve muscles and skin .
Aims/hypothesis. Skin and soft tissue infections (SSTIs) cause substantial morbidity in persons with diabetes. There are few data on pathogens or risk factors associated with important outcomes in diabetic patients hospitalised with SSTIs.
Pseudomonas colonization in a patient with severe burn wounds is acquired when normal skin/respiratory/ gastrointestinal flora is replaced by hospital flora; typical infections from P. aeruginosa occur several weeks after the initial burn. Colonization may be abetted by broad spectrum topical and/or systemic antibiotics. A trend toward a reduction in infection in the burn patient due to
The clinical manifestations, diagnosis, and treatment of P. aeruginosa skin, soft tissue, and bone infections will be reviewed here. The general principles of antimicrobial treatment of infections caused by P. aeruginosa , including antibiotic options and decisions on combination therapy, are discussed in detail elsewhere.
Clinical significance: Pseudomonas aeruginosa is a Gram-negative bacillus associated with a number of different opportunistic infections and is particularly problematic for ventilated patients, burn patients and those with chronic debilities.


Bilateral Necrotizing Soft Tissue Infection Caused by
How to manage Pseudomonas aeruginosa
Pseudomonas Infections Infections – Merck Manuals
Second Meeting of the Subcommittee of the Expert Committee on the Selection and Use of Essential Medicines Geneva, 29 September to 3 October 2008 Use of ceftazidime in children and options for treating pseudomonas infections Summary Ceftazidime, a third generation cephalosporin, has good in vitro activity against P aeruginosa and is clinically effective and safe in treating infections due to
Skin Biopsy is Predictive of Outcome in Experimental Sepsis by Multidrug- Resistant Pseudomonas aeruginosa Vassiliki Tziortzioti 1 , Haritini Petropoulou 2 , Thomas Tsaganos 1 , Aikaterini Spyridaki 1 ,
Skin, soft tissue, muscle and bone – Staphylococcus, Streptococcus, Clostridium species. Intracranial injuries – Staphylococcus and gram-negative rods. Orofacial and neck injuries – gram-positive cocci and mouth anaerobes.
Pseudomonas Skin Infection Clinical Features, Epidemiology, and Management Douglas C. Wu,1 Wilson W. Chan,2 Andrei I. Metelitsa,1 Loretta Fiorillo1 and Andrew N. Lin1
pseudomonas aeruginosa septicemia Online Textbook of
Skin and Soft Tissue Infections (SSTI) Panel Staging of Wounds Wounds are classified according to their degree of severity on a four point scale (8). Stage 1 is typified by alteration in skin color, texture and temperature with no overt lesion present and does not involve the dermis. Stage 2 describes instances whereby the epidermal and dermal layers of skin are breached as a result of a tear
superficial soft tissue infections Investigation of swabs from skin and superficial soft tissue infections Bacteriology B More: Policy and Strategy Cefotaxime 1g Powder for Solution for Injection or Infusion – PL 20117/0007 [PDF]
Indicated for complicated skin/skin structure infections, soft tissue infections and complicated intra-abdominal infections. Effective for gram-positive, gram-negative, anaerobic, and against multi-antibiotic resistant bacteria (such as Staphylococcus aureus [MRSA] and Acinetobacter baumannii ), but not effective for Pseudomonas spp. and Proteus spp.
Gram-negative infections (especially those caused by Pseudomonas species) should be suspected if a toe web infection does not respond to empiric antimicrobial therapy with first- or second-generation cephalosporins, as their spectrum of antimicrobial activity does not include P aeruginosa.
urinary tract infections and skin soft tissue infections are discussed. Antibiotic combinations are reviewed as well as an analysis of pharmacokinetic and pharmacodynamic parameters to optimize P. aeruginosa treatment. Limitations of current therapies, the potential for alternative drugs and new therapeutic options are also discussed. Keywords: bloodstream infection, ceftazidime-avibactam
The Gram-negative bacterium Pseudomonas aeruginosa is a major opportunistic pathogen that causes severe infections, such as pneumonia and bacteremia, in immunocompromised patients.
Treatment of Skin and Soft-Tissue Infections with
A similar lesion called ‘ecthyma gangrenosum’ is sometimes seen in immunocompromised or debilitated patients and is usually associated with Pseudomonas aeruginosa bacteraemia, 4 x 4 Greene, S.L., Su, W.P., and Muller, S.A. Pseudomonas aeruginosa infections of, the skin.
This medico-surgical emergency is a life-threatening, invasive, soft tissue infection caused by aggressive, usually gas-forming bacteria, which primarily involves the superficial fascia and extends rapidly along subcutaneous tissue planes with relative sparing of skin and underlying muscle.
The percentage of post-operative soft-tissue infections is presented in Fig.1B (n=20/group), where a significant increase (p38°C, tachycardia (heart rate >90 beats per minute), tachypnea (respiratory rate >24 breaths per minute) or abnormal white blood cell count (>12 000 or < 4000 cells/µL).
Soft-tissue infections include those in muscle, tendons, ligaments, fat, and skin. These infections can occur in deep puncture wounds, especially in the feet of children who are wearing sneakers and step on a nail. Pseudomonas bacteria can also infect pressure sores, burns, and wounds due to injuries or surgery. When these bacteria grow in soiled dressings, the dressings turn green and smell
normal skin flora and gram negative bacilli,particularlyPseudomonas aeruginosa.Invasive otitis media is a necrotizing infection frequently associated with P.pseudomonas .The organism gains access to …
Necrotising skin infections, the best known of which is necrotising fasciitis, are a medical and surgical emergency that require prompt debridement and appropriate intravenous antibiotics. Infections can be caused by single or multiple pathogens (e.g. S. pyogenes , Gram negatives, Clostridium ).
infections of skin and soft tissue has been reported earlier (1-3). In the present study an attempt has been made to use acetic acid as a sole antimicrobial agent for the treatment of pseudomonal wound infections and to substantiate the earlier findings reported. MATERIALS AND METHODS For this study, seven hospitalized patients with wound infections, not responding to traditional therapy for
Pseudomonas and Related Infections Infectious Diseases
Skin, Soft Tissue, & Bone Infections G. Volpe, MD November 9, 2011 Milot, Haiti . Skin & Soft Tissue Layers . Cellulitis • Definition: inflammation of dermal and subcutaneous tissues due to nonsuppurative bacterial invasion • Likely risk factors: o trauma, peripheral edema, tinea pedis, skin break, deep abscess • Pyogenic, bacterial infection: o Group A Streptococcus: fatty acid layer of
Blue light can selectively eradicate Pseudomonas aeruginosa infections of the skin and soft tissues, while preserving the outermost layer of skin, according to a proof-of-principle study led by
(usually associated with contact lens use), otitis externa, skin and soft tissue infections (including diabetic foot infections). Hospitalized patients may be colonized with P. aeruginosa on admission or during hospital stay.
Skin and soft tissue infections Hemorrhage and necrosis People with burns or wound infections It is the most common cause of infections of burn injuries and of the outer ear (otitis externa), and is the most frequent colonizer of medical devices (e.g., catheters). Pseudomonas can be spread by equipment that gets contaminated and is not properly cleaned or on the hands of healthcare workers
Background: Necrotizing soft tissue infection caused by Pseudomonas aeruginosa in monomicrobian culture is rare. Aim: We present the case of a bullous bilateral form of Pseudomonas aeruginosa necrotizing skin infection in a renal transplantation recipient. – canadian dermatology association acne guidelines Urinary tract infections caused by Pseudomonas aeruginosa: infections like burn wounds infection, skin wound infection and acute pneumonia. Quantitative analysis of elastase, phospholipase C, toxin A, and exoenzyme S was assessed in P. aeruginosa strains isolated from wound infections, respiratory tract infections and urinary tract infections by Hamood et al. [37] It was observed that …
Clinical approaches to patients with bacteremia, ventilator-associated pneumonia, urinary tract infections and skin soft tissue infections are discussed. Antibiotic combinations are reviewed as well as an analysis of pharmacokinetic and pharmacodynamic parameters to optimize P. aeruginosa …
The areas of the body that the infections are most likely to affect are the ears, skin, lungs, soft tissue, and blood. A Pseudomonas infection that reaches the bloodstream tends to be more severe
Patients with diabetic foot ulcers, pressure sores, bites, necrotising fasciitis, gangrene and third degree burns or burns covering more than 5% of their body were excluded, as were those with monomicrobial Pseudomonas aeruginosa or anaerobic infections. 1
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As the name specifies, skin and skin structure infections (also termed skin and soft tissue infections) are infections of the skin and surrounding soft tissue including the loose connective tissue and mucous membranes. Bacterial pathogens are usually the cause of skin and skin structure infections and these infections require systemic antibiotic therapy.
invades the host tissue and cause infection and bacteremia in immunocompromised hosts (e.g., HIV/AIDS, cystic fibrosis, bronchiectasis, and severe chronic obstructive pulmonary disease, burns, malignancy, or diabetes mellitus).
urinary tract infections, gastrointestinal infections, meningitis, and, commonly, septicaemia 13. P. P. aeruginosa is the most common agent associated with infection and inflammation during contact lens
Pseudomonas oryzihabitans An unusual cause of skin and
necrotizing soft tissue infections are combinations of staphylococci (especially Staphylococcus epidermidis with-hemolytic streptococci),enterococci,Enterobacteriaceae species (commonly
31/07/2018 · Ecthyma gangrenosum (EG) is a well-recognized but uncommon cutaneous infection classically associated with Pseudomonas aeruginosa bacteremia. EG usually occurs in patients who are critically ill and immunocompromised; it is almost always a sign of pseudomonal sepsis.
Pseudomonas aeruginosa. P. aeruginosa is an opportunistic pathogen that can cause a wide range of infections, especially in immunocompromised people and …
Pseudomonas infections can develop in many anatomic sites, including skin, subcutaneous tissue, bone, ears, eyes, urinary tract, lungs, and heart valves. The site varies with the portal of entry and the patient’s vulnerability. In hospitalized patients, the first sign may be overwhelming gram-negative sepsis.
skin and soft tissue infections, fasciitis, to urinary or respiratory infections, central nervous system infections, endocarditis etc. Few cases of sepsis caused by Myroides spp. have been described. Case presentation: We present the case of an immunocompromised patient with diabetes mellitus,
Pseudomonas aeruginosa is an opportunistic pathogen and individuals with suppressed immune systems, especially those with neutropenia (low white blood cell count), are most susceptible.
Skin and soft tissue infections, including wound infections, pyoderma and dermatitis. Pseudomonas aeruginosa can cause a variety of skin infections, both localized and diffuse. The common predisposing factors are breakdown of the integument which may result from burns, trauma or dermatitis; high moisture conditions such as those found in the ear of swimmers and the toe webs of athletes, …
Skin and soft tissue infections result from microbial invasion of the skin and its supporting structures. Management is determined by the severity and location of the infection and by patient
Pseudomonas aeruginosa Wikipedia
(PDF) Pathogenesis of intestinal Pseudomonas aeruginosa
Pseudomonas infections Causes symptoms and treatments
29/11/2013 · Pseudomonas aeruginosa is not a common aetiological agent of community-acquired skin and soft tissue infection with bacteremia. Its infections in community should be managed cautiously particularly in high-risk populations those are immunosuppressant. Treatment of
doxycycline, or clindamycin for the management of skin and soft tissue infections. Linezolid or daptomycin should only be considered when the S. aureus isolate is resistant to other agents or the patient is intolerant of these agents.
Pseudomonas infections of the skin vary from “hot tub” folliculitis (Chapter 447) to soft tissue infections of the external ear. Interdigital toe web infections that begin as simple tinea pedis can be complicated by superimposed Pseudomonas infection and …
Pseudomonas aeruginosa infections are often associated with intravenous drug abuse.2 Classification Skin and soft tissue infections represent a heterogeneous array of disorders. Several classifications have been proposed, but yet none is universally accepted. These are generally classified into two categories: purulent infections (e.g., furuncles, carbuncles, abscesses) and nonpurulent
Pseudomonas aeruginosa causes urinary tract infections, respiratory system infections, dermatitis, soft tissue infections, bacteremia, bone and joint infections, gastrointestinal infections and a variety of systemic infections, particularly in patients with severe burns and in cancer and AIDS patients who are immunosuppressed.
Pseudomonas aeruginosa has become an important cause of gram-negative infection, especially in patients with compromised host defense mechanisms. It is the most common pathogen isolated from
Pathogenesis of Pseudomonas Joanna B. Goldberg, Ph.D. Emory University School of Medicine March 1, 2017 Nothing to disclose. Mandell, Douglas, and …
Acute Otitis ExternaPathophysiologyClinicalpresentation
Urinary tract infections caused by Pseudomonas aeruginosa
Overview of Multidrug-Resistant Pseudomonas aeruginosa and
Pseudomonas aeruginosa is a Gram-negative bacillus that is most frequently associated with opportunistic infection, but which can also present in the otherwise healthy patient.
Pseudomonas aeruginosa is a Gram-negative bacillus that is most frequently associated with opportunistic infection, but which can also present in the otherwise healthy patient. The range of P. aeruginosa infections varies from localized infections of the skin to life-threatening systemic disease
P. aeruginosa is an opportunistic pathogen that rarely causes disease in healthy individuals. Most infections are able to take hold by the loss of the integrity of a physical barrier to infection (eg, skin, mucous membrane) or the presence of immune deficiency.
Basavraj Nagoba Bharat Wadher Prabhakar Kulkarni

Treatment of skin and soft tissue infections caused by

Skin soft tissue infections succumb to blue light

How to manage Pseudomonas aeruginosa infections Drugs in

Skin and Soft Tissue Infections (SSTI)
– Complicated skin and soft tissue infection Journal of
Journal Skin Biopsy is Predictive of Outcome in
List of antibiotics Wikipedia

Skin and Soft Tissue Infections UCLA

Ecthyma Gangrenosum Background Pathophysiology Etiology

Skin and Soft Tissue Infections American Academy of

Pseudomonas aeruginosa Information and Epidemiology Services
Journal Skin Biopsy is Predictive of Outcome in

The opportunistic gram-negative bacterium Pseudomonas aeruginosa is implicated in many chronic infections and is readily isolated from chronic wounds, medical devices, and the lungs of cystic
Blue light can selectively eradicate Pseudomonas aeruginosa infections of the skin and soft tissues, while preserving the outermost layer of skin, according to a proof-of-principle study led by
infections of skin and soft tissue has been reported earlier (1-3). In the present study an attempt has been made to use acetic acid as a sole antimicrobial agent for the treatment of pseudomonal wound infections and to substantiate the earlier findings reported. MATERIALS AND METHODS For this study, seven hospitalized patients with wound infections, not responding to traditional therapy for
Pseudomonas aeruginosa is a major cause of nosocomial infections. This organism shows a remarkable This organism shows a remarkable capacity to resist antibiotics, either intrinsically (because of constitutive expression of b-lactamases and
Skin and Soft Tissue Infections Cellulitis Note: The most common etiology of cellulitis with purulent drainage is S. aureus, although Group A streptococci and …
Multiple antibiotic resistant Pseudomonas aeruginosa is a significant cause of burn wound infections and, skin and soft tissue infections. Because of its resistance to commonly used antibiotics and antiseptics, there is a shortage of therapeutic options for effective treatment.
Aims/hypothesis. Skin and soft tissue infections (SSTIs) cause substantial morbidity in persons with diabetes. There are few data on pathogens or risk factors associated with important outcomes in diabetic patients hospitalised with SSTIs.
urinary tract infections and skin soft tissue infections are discussed. Antibiotic combinations are reviewed as well as an analysis of pharmacokinetic and pharmacodynamic parameters to optimize P. aeruginosa treatment. Limitations of current therapies, the potential for alternative drugs and new therapeutic options are also discussed. Keywords: bloodstream infection, ceftazidime-avibactam

Pseudomonas oryzihabitans An unusual cause of skin and
Skin and Soft Tissue Infections (SSTI) Think Big. We Do.

This information may then be used to determine whether antipseudomonal antibiotic drug therapy is indicated for DFI at this facility. were processed per routine laboratory protocol. or drainage at the suspected site of bone infection) plus an organism cultured from blood.388C. tenderness.bial skin and soft-tissue infections that include P aeruginosa can occur in the absence of antibiotic
Skin and soft tissue infections (SSTIs) due to Pseudomonas oryzihabitans are very rare. The aim of the present study was to investigate the clinical and microbiological characteristics of this
Abstract. Skin and soft-tissue infections due to Pseudomonas aeruginosa were treated with intravenous infusions or intramuscular injections of cefsulodin sodium in an open, multi-center study.
Pseudomonas colonization in a patient with severe burn wounds is acquired when normal skin/respiratory/ gastrointestinal flora is replaced by hospital flora; typical infections from P. aeruginosa occur several weeks after the initial burn. Colonization may be abetted by broad spectrum topical and/or systemic antibiotics. A trend toward a reduction in infection in the burn patient due to
infections of skin and soft tissue has been reported earlier (1-3). In the present study an attempt has been made to use acetic acid as a sole antimicrobial agent for the treatment of pseudomonal wound infections and to substantiate the earlier findings reported. MATERIALS AND METHODS For this study, seven hospitalized patients with wound infections, not responding to traditional therapy for
Pseudomonas aeruginosa. P. aeruginosa is an opportunistic pathogen that can cause a wide range of infections, especially in immunocompromised people and …
Pseudomonas aeruginosa has become an important cause of gram-negative infection, especially in patients with compromised host defense mechanisms. It is the most common pathogen isolated from
Clinical approaches to patients with bacteremia, ventilator-associated pneumonia, urinary tract infections and skin soft tissue infections are discussed. Antibiotic combinations are reviewed as well as an analysis of pharmacokinetic and pharmacodynamic parameters to optimize P. aeruginosa …
normal skin flora and gram negative bacilli,particularlyPseudomonas aeruginosa.Invasive otitis media is a necrotizing infection frequently associated with P.pseudomonas .The organism gains access to …
urinary tract infections, gastrointestinal infections, meningitis, and, commonly, septicaemia 13. P. P. aeruginosa is the most common agent associated with infection and inflammation during contact lens
Gram-negative bacilli Pseudomonas aeruginosa is an important pathogen in hospitalized patients, contributing to their morbidity and mortality due to its multiple resistance mechanisms. Therefore, as therapeutic options become restricted,
Pseudomonas aeruginosa is an opportunistic pathogen and individuals with suppressed immune systems, especially those with neutropenia (low white blood cell count), are most susceptible.
Anti-tumor necrosis factor alpha (TNF-α) therapy has been associated with an increased risk of granulomatous infections. We present a case of osteomyelitis and soft tissue abscess caused by Pseudomonas aeruginosa following the use of etanercept, a recombinant protein composed of the TNF-α receptor fused to human immunoglobulin (IgG).
invades the host tissue and cause infection and bacteremia in immunocompromised hosts (e.g., HIV/AIDS, cystic fibrosis, bronchiectasis, and severe chronic obstructive pulmonary disease, burns, malignancy, or diabetes mellitus).
31/07/2018 · Ecthyma gangrenosum (EG) is a well-recognized but uncommon cutaneous infection classically associated with Pseudomonas aeruginosa bacteremia. EG usually occurs in patients who are critically ill and immunocompromised; it is almost always a sign of pseudomonal sepsis.

Pseudomonas aeruginosa Wikipedia
Pseudomonas Infection an overview ScienceDirect Topics

31/07/2018 · Ecthyma gangrenosum (EG) is a well-recognized but uncommon cutaneous infection classically associated with Pseudomonas aeruginosa bacteremia. EG usually occurs in patients who are critically ill and immunocompromised; it is almost always a sign of pseudomonal sepsis.
A similar lesion called ‘ecthyma gangrenosum’ is sometimes seen in immunocompromised or debilitated patients and is usually associated with Pseudomonas aeruginosa bacteraemia, 4 x 4 Greene, S.L., Su, W.P., and Muller, S.A. Pseudomonas aeruginosa infections of, the skin.
Pseudomonas aeruginosa is a Gram-negative bacillus that is most frequently associated with opportunistic infection, but which can also present in the otherwise healthy patient.
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This medico-surgical emergency is a life-threatening, invasive, soft tissue infection caused by aggressive, usually gas-forming bacteria, which primarily involves the superficial fascia and extends rapidly along subcutaneous tissue planes with relative sparing of skin and underlying muscle.
Necrotising skin infections, the best known of which is necrotising fasciitis, are a medical and surgical emergency that require prompt debridement and appropriate intravenous antibiotics. Infections can be caused by single or multiple pathogens (e.g. S. pyogenes , Gram negatives, Clostridium ).
Pathogenesis of Pseudomonas Joanna B. Goldberg, Ph.D. Emory University School of Medicine March 1, 2017 Nothing to disclose. Mandell, Douglas, and …

PSEUDOMONAS SPP. uta.edu
TG273 IC excerpts IAFF Main

Pseudomonas aeruginosa is a major cause of nosocomial infections. This organism shows a remarkable This organism shows a remarkable capacity to resist antibiotics, either intrinsically (because of constitutive expression of b-lactamases and
P. aeruginosa is an opportunistic pathogen that rarely causes disease in healthy individuals. Most infections are able to take hold by the loss of the integrity of a physical barrier to infection (eg, skin, mucous membrane) or the presence of immune deficiency.
{{configCtrl2.info.metaDescription}}
infections of skin and soft tissue has been reported earlier (1-3). In the present study an attempt has been made to use acetic acid as a sole antimicrobial agent for the treatment of pseudomonal wound infections and to substantiate the earlier findings reported. MATERIALS AND METHODS For this study, seven hospitalized patients with wound infections, not responding to traditional therapy for
invades the host tissue and cause infection and bacteremia in immunocompromised hosts (e.g., HIV/AIDS, cystic fibrosis, bronchiectasis, and severe chronic obstructive pulmonary disease, burns, malignancy, or diabetes mellitus).
Pseudomonas Skin Infection Clinical Features, Epidemiology, and Management Douglas C. Wu,1 Wilson W. Chan,2 Andrei I. Metelitsa,1 Loretta Fiorillo1 and Andrew N. Lin1
Skin and Soft Tissue Infections Cellulitis Note: The most common etiology of cellulitis with purulent drainage is S. aureus, although Group A streptococci and …
Necrotizing fasciitis (NF) is a severe soft tissue potentially fatal bacterial infection characterized by rapid progressing necrosis involving mainly the fascia and subcutaneous tissue but can also extend to involve muscles and skin .
Anti-tumor necrosis factor alpha (TNF-α) therapy has been associated with an increased risk of granulomatous infections. We present a case of osteomyelitis and soft tissue abscess caused by Pseudomonas aeruginosa following the use of etanercept, a recombinant protein composed of the TNF-α receptor fused to human immunoglobulin (IgG).
Abstract. Skin and soft-tissue infections due to Pseudomonas aeruginosa were treated with intravenous infusions or intramuscular injections of cefsulodin sodium in an open, multi-center study.